The exocytotic fusion pore modeled as a lipidic pore
نویسندگان
چکیده
منابع مشابه
The exocytotic fusion pore
T hE fusion pore is the molecular structure that transiently connects the lumens of two membrane compartments during their fusion. The fusion of membrane compartments occurs in all cells because intracellular trafficking of vesicles in both endocytic and exocytic pathways and in consti-tutive exocytosis are ubiquitous cellular processes. In addition, many other cells including endocrine, exocri...
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In 2013, the Nobel prize was awarded for discoveries related to the regulation of the cellular transport system (https://www.nobelprize.org/nobel_prizes/medicine/ laureates/2013/). In addition to studies by Südhof’s lab of signals that tell secretory vesicles when to release their cargo and the work of Schekman’s lab describing a set of genes required for vesicle transport, the Rothman’s lab de...
متن کاملThe fusion pore.
The secretory process requires many different steps and stages. Vesicles must be formed and transported to the target membrane. They must be tethered or docked at the appropriate sites and must be prepared for fusion (priming). As the last step, a fusion pore is formed and the contents are released. Release of neurotransmitter is an extremely rapid event leading to rise times of the postsynapti...
متن کاملThe exocytotic fusion pore of small granules has a conductance similar to an ion channel
We measured capacitance changes in cell attached patches of human neutrophils using a high frequency lock-in method. With this technique the noise level is reduced to 0.025 fF such that capacitance steps of 0.1 fF are clearly detected corresponding to exo- and endocytosis of single 60 nm vesicles. It is thus possible to detect almost all known exocytotic and endocytotic processes including exoc...
متن کاملCdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension
Membrane fusion underlies multiple processes, including exocytosis of hormones and neurotransmitters. Membrane fusion starts with the formation of a narrow fusion pore. Radial expansion of this pore completes the process and allows fast release of secretory compounds, but this step remains poorly understood. Here we show that inhibiting the expression of the small GTPase Cdc42 or preventing its...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1992
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(92)81679-x